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Gout May Lessen Alzheimer Risk: Study - Yahoo News

Gout may protect brain from Alzheimer?s disease, study finds | Fox News

The same uric acid that can crystallise to cause gout, a form of arthritis, mayprotect against Alzheimer's, they wrote in the online journal Annals of the Rheumatic Diseases. Testing a theory that antioxidant properties in uric acid may protect the brain, experts from the United States and Canada looked at the records of 3.7 million people over the age of 40 in a British database of medical charts. Researchers compared data on people with gout, and those without, who developed Alzheimer's disease in a followup period of about five years. The researchers identified 309 new cases of Alzheimer's among 59,224 gout sufferers with an average age of 65, and 1,942 cases among 238,805 non-sufferers. This amounted gout foods to a 24 percent lower risk of Alzheimer's disease for people with a history of reduce gout swelling gout, after factoring in differences in age, gender, bodyweight, lifestyle and health. "Our findings provide the first population-based evidence for the potential protective effect of gout on the risk of AD (Alzheimer's disease) and support the purported neuroprotective role of uric acid," the authors said in a statement. Gout happens when excess uric acid builds up in the blood, causing crystals to form around the joints, inflicting extreme pain and swelling.
For the original version including any supplementary images or video, visit http://news.yahoo.com/gout-may-lessen-alzheimer-risk-study-152116492.html

Gout may lessen chances of developing Alzheimer's disease | EurekAlert! Science News

The team conducted a study using data from The Health Improvement Network (THIN), an electronic medical record database from general practices that is representative of the UK general population, from 1 January 1995 to 31 December 2013. They looked at 3.7 million people aged 40 and over who had been registered and enrolled with a practice for at least one year during the period studied. Individuals diagnosed with gout or any dementia prior to the start of follow-up were excluded from the study. Analysis was carried out of Alzheimer's disease amongst adults with gout compared with up to five non-gout individuals matched by age, date of study entry, enrolment year and body mass index (BMI) using the THIN data. Participants were followed up until they developed Alzheimer's disease, died, left the THIN database or the follow-up ended, whichever came first. Overall, the researchers identified 309 new cases of Alzheimer's disease among 59,224 patients with gout (average age of 65) and 1,942 cases among 238,805 people in the comparison group over an average five-year follow up.
For the original version including any supplementary images or video, visit http://www.eurekalert.org/pub_releases/2015-03/b-gml030215.php

View photo The same uric acid that can crystallise to cause gout, a form of arthritis, mayprotect against Alzheimer's, researchers say (AFP Photo/Emmanuel Dunand) Paris (AFP) - People who suffer from gout can take comfort in one thing: they may be less likely to develop Alzheimer's disease, researchers said Wednesday. The same uric acid that can crystallise to cause gout, a form of arthritis, may protect against Alzheimer's, they wrote in the online journal Annals of the Rheumatic Diseases. Testing a theory that antioxidant properties in uric acid may protect the brain, experts from the United States and Canada looked at the records of 3.7 million people over the age of 40 in a British database of medical charts. Researchers compared data on people with gout, and those without, who developed Alzheimer's disease in a followup period of about five years. The researchers identified 309 new cases of Alzheimer's among 59,224 gout sufferers with an average age of 65, and 1,942 cases among 238,805 non-sufferers. This amounted to a 24 percent lower risk of Alzheimer's disease for people with a history of gout, after factoring in differences in age, gender, bodyweight, lifestyle and health.
For the original version including any supplementary images or video, visit http://news.yahoo.com/gout-may-lessen-alzheimer-risk-003621091.html

Gout may lessen Alzheimer risk - Yahoo News

ADVERTISEMENT ADVERTISEMENT Results showed that among the 3.7 million patients over age 40 who were analyzed, those people with a history of gout were at a 24 percent lower risk of Alzheimers compared to those who didnt have the condition. Previous research has suggested that antioxidant properties found in uric acid, the chemical in a person's blood that can crystallize and lead to gout, may protect against the development or progression of neurodegenerative conditions. Study author Dr. Hyon Choi, medicine professor at Harvard Medical School, told FoxNews.com that several other factors prompted his teams research. As a major natural antioxidant in the body, uric acid has been estimated to account for more than 50 percent of the antioxidant capacity of plasma, he said. With these potentially neuro-protective properties, uric acid has been hypothesized to protect against oxidative stress, a prominent contributor to dopaminergic neuron degeneration in Parkinson's disease, which may also play an important role in the pathogenesis of Alzheimers disease. Study authors hypothesize that uric acid is the reason for the protective effect on the brain. Choi said there is evidence that it preserves mitochondrial function in the body and repairs free radical-induced DNA damage. The study provides the first population-based evidence for the potential protective effect of gout on the risk of Alzheimers disease and supports the supposed neuro-protective role of uric acid.
For the original version including any supplementary images or video, visit http://www.foxnews.com/health/2015/03/05/gout-may-protect-brain-from-alzheimers-disease-study-finds/

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